Clenbuterol: properties, uses.
Clenbuterol is widely used around the world as a bronchodilator. Maple. belongs to the group of sympathomimetics – drugs that act on the nervous system, its adrenergic receptors. There are 9 types of adrenergic receptors in the body, which are classified as alpha and beta receptors. Depending on the receptor, the drug can act on a variety of problems – asthma, hypertension, arrhythmia, migraine or suppression of anaphylactic shock.
In Therapeutics Pharmacological Foundation 9th Edition, Goodman and Gilman state the following:
The effects of most catecholamines and sympathizers can be divided into 7 types:
1) peripheral excitatory effect on certain types of smooth muscles, such as subcutaneous vessels, kidneys and mucous membranes, in glandular cells, in particular salivary and sweat glands.
2) peripheral narrowing effect on other types of smooth tissue: intestinal tissue, bronchial tissue, skeletal muscle blood vessels.
3) excitatory effect on the heart, increasing the frequency of its contractions.
4) metabolic changes – increased burning of glycogen in the liver and muscles, release of fatty acids from adipose tissue.
5) effects on the endocrine system – modulation of the release of insulin, renin and pituitary hormones.
6) effects on the central nervous system – excitation of the respiratory tract, increased psychomotor activity and decreased appetite
7) a presynaptic effect that blocks or stimulates the release of neurotransmitters such as norepinephrine and acetylcholine.
Clenbuterol is a very effective drug
Clenbuterol is a selective beta-2 sympathomimetic that acts on only one of three groups of beta-adrenergic receptors, although it has some ability to act on beta-1 receptors, thus avoiding some of the side effects associated with the cardiovascular system . Clinical studies have shown Clenbuterol to be a very effective bronchodilator with several reports of adverse effects after its use.
Clenbuterol has a very long half-life, around 34 hours. This makes it easier to achieve and maintain a working blood concentration. This means that you only need to take the dose once or twice a day. Clenbuterol is a very controversial drug and there are many rumors circulating about it.
For example, rumors about its anabolic activity have been spreading for a long time – in 1995 a study was published in the journal Medicine and Science in Sports and Exercise, which showed that anabolic activity in the human body is questionable, although its possible anabolistic effects were still debated.
Clenbuterol is not only a popular drug in the arsenal of modern bodybuilders, it can actually be called a legendary drug. In addition to the above properties, clenbuterol has many properties that are not known to the “broad masses” of bodybuilding fans, but allow us to talk about the drug as something truly extraordinary.
Clenbuterol, taken in small amounts (20-40 mcg) 1-2 hours before exercise, may slightly improve its quality. What do I mean by quality? In this case, the drug can significantly increase your strength and increase blood flow to your muscles.
Trust me, I know what I’m talking about – “pump” for “maple” is just amazing.
If you take this medication regularly, take 1 tablet (40 mcg) of clenbuterol before training and the remaining daily dose after training. However, it should be noted that clenbuterol to some extent reduces the body’s ability to store glycogen, although accidental use may have only a negligible effect on this process.
Clenbuterol and muscle growth
Thus, Clenbuterol can be a very good anti-catabolic agent in a strict pre-competitive diet. As for the period of muscle building, when the sportsman’s diet does not suffer from a lack of calories, but on the contrary, often the same calories contain too many, “maple” does not show its catabolic properties. So what is the point of using this drug “by weight”? But no! Strange, but here are the catabolic properties of clenbuterol in high doses.
Yuri Bombel’s article on Clenbuterol says: At doses ranging from 300 to 400 mcg per day, the drug is a powerful catabolic substance that damages muscle fibers very well. But what about catabolism – the main enemy of muscle mass – to recruit it? And here’s what. Make a reservation now – Clenbuterol’s catabolic properties are only beneficial for athletes taking androgenic drugs during exercise, especially those prone to aromatization. The fact is that one of the beneficial properties of estradiol, which tends to be affected by the aromatase enzyme, is the protection of cells against damage.
Many people know that muscle soreness caused by muscle fiber damage goes away quickly during the “steroid cycle”. Estradiol is responsible for this. And Clenbuterol can improve the situation.
At first glance, everything is fine – no pain, which means you can train more often. But… “No pain, no gain” – “without pain, there is no success”, for bodybuilding, this formula is right! Without damage, muscle fibers lose one of their most powerful growth stimuli. Additionally, training stimulates cells to produce increased levels of IGF-1 and prostaglandins and increases cell sensitivity to these substances.
However, for IGF-1 and prostaglandins to enter the general circulation (often their autocrine effects, i.e. the effect on the cell in which they are synthesized, are very limited), it is necessary damage the cell membrane. Clenbuterol comes to the rescue.
Use of Clenbuterol and its properties
Aromatization, as you have already learned, is not always a negative phenomenon. High levels of estradiol in the blood contribute to the accelerated accumulation of glycogen in the muscles, as well as the upregulation (increase in number) of androgen receptors. The high levels of estradiol that cause the use of Clenbuterol help to achieve even more impressive muscle growth results.
High, but not above a certain limit, beyond which male estradiol becomes an enemy. Thus, clenbuterol, a β2-adrenergic agonist, contributes significantly to the process of androgen aromatization. Of course, with its regular use. This property of clenbuterol can be very useful for drugs with a very low “aromatization score”, but when testosterone or metandrostenolone is used in combination with clenbuterol, accelerating the aromatization process can have very serious consequences. negative. The only correct solution would be to use Clenbuterol after the treatment with the steroids described above.
In conclusion, I would like to add that all the properties of Clenbuterol presented in this article have been taken from reputable and reliable publications. There is therefore no reason to doubt their authenticity. Moreover, you can easily confirm my words by referring to the work of our old friend Yuri Bombel.
Contrary to popular belief, local – “on-the-spot” – fat burning is possible with the use of Clenbuterol, as Yuri Bombela mentioned in his Anabolic Review showed those who try to achieve this usually don’t. not in the areas where they direct their efforts. Adipose tissue, like muscle tissue, is penetrated by nerve fibers. The brain interacts with tissues (including fat) through neurotransmitters such as epinephrine and norepinephrine. The first and the second, in this case, are hormones that are powerful enough to burn fat. Theoretically, we can burn fat without using clenbuterol, with pure willpower, by directing neurotransmitters exactly where they are needed. But only in theory.
In practice, adrenaline and norepinephrine can be targeted to areas where accelerated fat burning is desired by local injections of clenbuterol. This deserves to be emphasized from the outset: if you hope to obtain a visible result with one or two injections, you should not even try this technique to avoid bitter disappointment. The visible result is visible only after a month and a half of regular repeated injections and only with a relatively strict diet.
Of the Clenbuterol liquid formulations produced, I am only aware of Ventipulmin, a syrup (355ml bottle, active ingredient concentration 25mg/ml) manufactured by Boehringer-Ingelheim. However, liquid salbutamol can also be used as a substitute for “maple” in this case, since preparations containing it as an active substance can be purchased at almost any pharmacy.